Leukocytosis-Promoting Factor of Bordetella pertussis II. Biological Properties
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چکیده
منابع مشابه
Leukocytosis-promoting factor of Bordetella pertussis. II. Biological properties.
The leukocytosis-promoting factor (LPF), purified from materials extracted from agar in which Bordetella pertussis was grown, caused leukocytosis and an increased sensitivity to histamine when as little as 0.04 mug of protein was given intravenously to mice. LPF was adsorbed onto erythrocytes, causing hemagglutination. As little as 0.03 mug of LPF protein agglutinated chicken erythrocytes in 0....
متن کاملLeukocytosis-promoting factor of Bordetella pertussis.
The leukocytosis-promoting factor (LPF), purified from materials extracted from agar in which Bordetella pertussis was grown, caused leukocytosis and an increased sensitivity to histamine when as little as 0.04 Ag of protein was given intravenously to mice. LPF was adsorbed onto erythrocytes, causing hemagglutination. As little as 0.03 ,g of LPF protein agglutinated chicken erythrocytes in 0.05...
متن کاملIsolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis
The leukocytosis- and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated to near homogeneity by physical, chemical, and electron microscopical criteria. LPF contains 14.5% nitrogen and is lipid and carbohydrate free. It is apparently composed of four polypeptide subunits. LPF caused leukocytosis and lymphocytosis in "nude" as well as in normal mice. In addition, puri...
متن کاملLeukocytosis-promoting factor of Bordetella pertussis. 3. Its identity with protective antigen.
Leukocytosis-promoting factor (LPF) was purified from the supernatant of a 5-day liquid culture of Bordetella pertussis strains Tohama and no. 134. The preparations appeared to be filamentous molecules (2 by 40 nm) and contained histamine-sensitizing and hemagglutinin activities in addition to leukocytosis-promoting activity. Active protection tests in mice demonstrated strong protective activi...
متن کاملStudies on the Leukocytosis and Lymphocytosis Induced by Bordetella Pertussis
By the use of radioautographic techniques it was shown that the lymphocytosis induced by Bordetella pertussis in mice was not caused by an increased production of lymphocytes but was primarily due to the entry into the circulation of mature cells from tissue pools. The accompanying polymorphonuclear leukocytosis was due to both proliferation of myeloid elements and entry of mature cells from ti...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1973
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.7.6.992-999.1973